8/22/2023 0 Comments Download avp ps1We have reported that AVP rescues Aβ-induced impairments of spatial memory, hippocampal long-term potentiation (LTP), and spontaneous discharges in rats. On the contrary, administration of AVP has been reported to facilitate learning and memory, and enhance synaptic plasticity and the expression of synapse-related protein in the hippocampus. Previous research has shown that AVP-deficient rats have poor social discrimination, object discrimination, and conditioned learning mice with V1a and V1b receptor knockout have deficits in mnemonic function and administration of AVP receptor antagonists leads to memory impairment in rats. Interestingly, a significant decrease in arginine vasopressin (AVP) has been found in the cerebrospinal fluid and many brain regions, especially in the hippocampus of AD patients.ĪVP, traditionally associated with the regulation of water balance and blood pressure in the periphery, has been considered as a neurotransmitter and/or neuromodulator in the central neural system (CNS) and affects diverse aspects of cognitive ability such as the consolidation and retrieval of memory. Multiple pathological characteristics of AD have been identified in the brain, including amyloid-beta (Aβ) deposits, tau hyperphosphorylation, neurotrophic factor dysregulation, and synaptic deficits. These results reveal the beneficial effects of AVP(4-8) in APP/PS1-AD mice, showing that the intranasal administration of AVP(4-8) effectively improved the working memory and long-term spatial memory of APP/PS1-AD mice, which may be associated with the elevation of PSD95 and NGF levels in the brain and the maintenance of hippocampal synaptic plasticity.Īlzheimer’s disease (AD) is an insidious degenerative disease of the brain characterized by progressive cognitive deficits, memory loss, and specific neuropsychiatric anomalies. The results showed that: (1) APP/PS1-AD mice had lower spontaneous alternation in the Y-maze than wild-type (WT) mice, and this was significantly reversed by AVP(4-8) (2) the prolonged escape latency of APP/PS1-AD mice in the Morris water maze was significantly decreased by AVP(4-8), and the decreased swimming time in target quadrant recovered significantly after AVP(4-8) treatment (3) in vivo hippocampal LTP induced by high-frequency stimulation had a significant deficit in the AD mice, and this was partly rescued by AVP(4-8) (4) AVP(4-8) significantly up-regulated the expression levels of postsynaptic density 95 (PSD95) and nerve growth factor (NGF) in the hippocampus of AD mice. Here, we investigated for the first time the neuroprotective effects of AVP(4-8) on memory behaviors and in vivo long-term potentiation (LTP) in APP/PS1-AD mice. However, it is not clear whether AVP(4-8) can improve cognitive behaviors and synaptic plasticity in the APP/PS1 mouse model of AD. AVP(4-8), different from its precursor AVP, plays memory enhancement roles in the CNS without peripheral side-effects. Memory deficits with aging are related to the neurodegeneration in the brain, including a reduction in arginine vasopressin (AVP) in the brain of patients with Alzheimer’s disease (AD).
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